Tell your doctor if you have sexual side effects while you’re taking duloxetine oral capsules. Your doctor can help you figure out if the side effects are from duloxetine or the condition you’re treating. Mild side effects of many drugs may go away within a few days or a couple of weeks. https://sober-house.net/blood-alcohol-content-bac-what-it-is-levels/ But if they become bothersome, talk with your doctor or pharmacist. Duloxetine oral capsules are a generic drug, which means they’re an exact copy of the active drug in a brand-name medication. The brand-name medication that duloxetine oral capsules are based on is called Cymbalta.
Post-traumatic Stress Disorder
Keep in mind that duloxetine is used to treat depression, which can cause weight gain or weight loss. But it could be due to your depression getting better and not because of the drug itself. Call your doctor right away if you have an allergic reaction to duloxetine oral capsules.
- Cymbalta is in a class of drugs called selective serotonin and norepinephrine reuptake inhibitors (SNRIs).
- If you notice any of these symptoms in your newborn, tell the doctor promptly.
- There was no significant difference in the frequency of sustained (3 consecutive visits) elevated blood pressure [see WARNINGS AND PRECAUTIONS].
- Taking doxorubicin with duloxetine may increase the amount of doxorubicin in your body.
Side effects and risks
Data from published literature report the presence of duloxetine in human milk (see Data). There are reports of sedation, poor feeding, and poor weight gain in infants exposed to duloxetine through breast milk (see Clinical Considerations). There are no data on the effect of duloxetine on milk production. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown.
FDA warning: Suicidal thoughts and behaviors
Do not take duloxetine within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others. Duloxetine is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Duloxetine oral capsules may not be right for you if you have certain medical conditions or other factors that affect your health.
What is duloxetine (Cymbalta) and what is it used for?
Below are lists of medications that can interact with Cymbalta. These lists do not contain all drugs that https://sober-home.org/substance-use-and-co-occurring-mental-disorders/ may interact with Cymbalta. For instance, some interactions can interfere with how well a drug works.
Side effects in children
If you have questions about whether an SSRI or SNRI is right for treating your condition, talk with your doctor. There haven’t been studies on whether Cymbalta can cause drug dependence. Studies in rats didn’t show a risk of dependence, but animal studies do not always predict what will happen in humans. If you and your doctor determine that Cymbalta is safe and effective for you, you’ll likely take it long term. The following information describes dosages that are commonly used or recommended.
Remember, your doctor and other healthcare professionals are available to help you. So don’t be afraid to ask questions or offer feedback on your treatment. Many insurance companies require prior authorization for this drug.
Do not start, stop, or change the dose of any drug without checking with your doctor. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene lsd abuse is acid addictive and how is it abused blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and at least 5 days after treatment with this medication.
Always consult a healthcare provider for personalized medical advice. Cymbalta, known by the active ingredient and generic name duloxetine, is a prescription drug used to treat depression, anxiety, and diabetic nerve pain. It is also approved for fibromyalgia and chronic muscle pain. Cymbalta works as a serotonin-norepinephrine reuptake inhibitor (SNRI) to improve mood and alleviate pain. Duloxetine is a type of antidepressant known as a serotonin–norepinephrine reuptake inhibitor used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain).
Steady-state plasma concentrations are typically achieved after 3 days of dosing. Elimination of duloxetine is mainly through hepatic metabolism involving two P450 isozymes, CYP1A2 and CYP2D6. CYMBALTA is in a class of drugs known to affect urethral resistance [see WARNINGS AND PRECAUTIONS]. Activated charcoal may be useful in limiting absorption of duloxetine from the gastrointestinal tract.
Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors in vitro. These effects were observed at the high dose of 45 mg/kg/day (2 times the MRHD, for a child); the no-effect-level was 20 mg/kg/day (≈1 times the MRHD, for a child). It is important for prescribers to inquire about sexual function prior to initiation of CYMBALTA and to inquire specifically about changes in sexual function during treatment, because sexual function may not be spontaneously reported.
Subgroup analyses did not indicate that there were any differences in treatment outcomes as a function of age or gender. Duloxetine bioavailability (AUC) appears to be reduced by about one-third in smokers. Infants exposed to CYMBALTA should be monitored for sedation, poor feeding and poor weight gain. Duloxetine was not mutagenic in the in vitro bacterial reverse mutation assay (Ames test) and was not clastogenic in an in vivo chromosomal aberration test in mouse bone marrow cells. Advise patients to swallow CYMBALTA whole and to not chew, crush, or open the capsule (do not sprinkle contents on food or mixed with liquids) because these actions might affect the enteric coating.
The information in this section describes commonly used or recommended dosages. But be sure to take the dosage your doctor prescribes for you. Cymbalta has been prescribed off-label for the treatment of urinary incontinence, specifically stress urinary incontinence. The medication may help strengthen the muscles that control urine flow and improve overall bladder function.
